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charmilles edm 8516080 1

Selleck製品は、NatureやScience等の権威ある科学雑誌に掲載された論文中で数多く使用されています。

Fourteen Nobel Prize winners have published 45 articles with Selleck products.

THE NOBEL PRIZE

David Julius

Won the Nobel Prize in Physiology or Medicine in 2021

Michael Houghton

Won the Nobel Prize in Physiology or Medicine in 2020

Charles M. Rice

Won the Nobel Prize in Physiology or Medicine in 2020

William G. Kaelin Jr

Won the Nobel Prize in Physiology or Medicine in 2019

Peter J. Ratcliffe

Won the Nobel Prize in Physiology or Medicine in 2019

Gregg L. Semenza

Won the Nobel Prize in Physiology or Medicine in 2019

James P. Allison

Won the Nobel Prize in Physiology or Medicine in 2018

Michael Rosbash

Won the Nobel Prize in Physiology or Medicine in 2017

Shinya Yamanaka

Won the Nobel Prize in Physiology or Medicine in 2012

Eric Richard Kandel

Won the Nobel Prize in Physiology or Medicine in 2000

Aziz Sancar

Won the Nobel Prize in Chemistry in 2015

Brian K. Kobilka

Won the Nobel Prize in Chemistry in 2012

Robert Lefkowitz

Won the Nobel Prize in Chemistry in 2012

Aaron Ciechanover

Won the Nobel Prize in Chemistry in 2004

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製品コード 製品名 Target Pathway 製品説明
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S8913 TH5487 Others Others TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM.
S8938 KGA-2727 SGLT GPCR & G Protein KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.
S8939 Mizagliflozin SGLT GPCR & G Protein Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
S7013 Guadecitabine (SGI-110) Others Others Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine.
S8812 CM272 DNA Methyltransferase Epigenetics CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death.
S9729 Visomitin (SKQ1) Others Others INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively.
S8500 BAY1125976 Akt PI3K/Akt/mTOR BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).